Brooks County shocks Tift County
Garrick Davis scored on 1- and 8-yard runs, Robert Williams added a 1-yard touchdown run and linebacker Derek Carter scored on an interception return.
Michael Thompson added 31-yard field goal.
Houston County will face Bradwell Institute at home on Friday.
Lowndes was tested by 2006 co-state champion Peachtree Ridge on Friday, but still came away with a 22-6 victory at Martin Stadium. The Vikings, ranked No. 2 in the nation, rolled up 270 yards of offense and took advantage of two interceptions and 90 yards of Lions penalties.
Sophomore Tyler Hunter had a big night for the Vikings, running 95 yards for one touchdown and throwing 29 yards to Gerald Demps for another.
Robert Anderson ran 36 yards for the Vikings other touchdown.
Lowndes, 2-0 and on a 16-game winning streak, will play host to 1-1 Ware County on Friday.
On Saturday, Northside-Warner Robins won its 32nd straight game, defeating Booker T. Washington High of Miami, Fla., 31-6 at McConnell-Talbert Stadium.
The Tornadoes won the 2007 Class 4A Florida state title.
The Eagles will face a second-straight defending state champion when they travel to Columbus to take on Carver High on Friday.
Carver won the Class AAA title last year, defeating Cairo in the championship game.
On Thursday, two Region 1-AAAAA teams remained undefeated, winning games that were moved up in anticipation of bad weather associated with Tropical Storm Hanna.
Like Houston County, Coffee posted its second straight shutout, taking down Pierce County 41-0 at Jardine Stadium.
Coffee rolled up 384 yards of offense, with quarterback L’Shaun Smith completing 6-of-8 passes for 145 yards and one touchdown.
Simeon Goolsby had a 40-yard punt return for a touchdown, Mark Wilson ran three times for 35 yards and a score and tight end Corey Davis had two receptions for 86 yards and a touchdown.